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Self-Study Modules and Sections

  1. For any clinician who may encounter persons with hepatitis C virus infection and would like to establish core competence in testing for hepatitis C, counseling patients on preventing hepatitis C transmission, and diagnosing acute hepatitis C infection.
  2. Intended for clinicians involved in long-term management of persons with chronic hepatitis C infection. Content includes initial evaluation, natural history, preventing liver damage, staging of liver fibrosis, evaluation of cirrhosis, surveillance for hepatocellular carcinoma, and recognition of extrahepatic manifestations.
  3. Addresses the diagnosis and management of complications that may arise in person with chronic HCV infection and cirrhosis, including ascites, spontaneous bacterial peritonitis, varicies, hepatic encephalopathy, and referral for liver transplantation.
  4. For clinicians evaluating persons with chronic HCV infection for hepatitis C treatment, including clinicians who will independently assess treatment candidacy and clinicians who will provide treatment candidacy with assistance from a hepatitis C expert.
  5. For clinicians treating chronic hepatitis C infection. Material covered includes recommendations for treatment-naïve and treatment-experienced persons with chronic HCV infection genotypes 1-6, based on the Association for the Study of Liver Diseases and Infectious Diseases Society of America (AASLD-IDSA) HCV Guidance.
  6. Designed for clinicians who manage key populations of persons living with HCV and/or complex HCV-related unique treatment issues. Material covered is at an advanced level.

Core Competencies for the Hepatitis C Online

The following is an outline and list of Core Competency Modules (with sub-competency lessons and learning objective performance indicators).

Module 1. Screening and Diagnosis of Hepatitis C Infection

Module Core Competency
Apply Evidence-Based Recommendations to Provide Screening and Diagnosis of HCV Infection
Lessons
Learning Objective Performance Indicators
  • Describe the epidemiologic profile of the hepatitis C epidemic in the United States
  • Discuss application of HCV epidemiological data in public health planning
  • Identify key risk factors and their mitigation for transmission of HCV
  • Describe the impact of the ongoing opioid epidemic on trends in HCV epidemiology
  • Summarize Centers for Disease Control and Prevention (CDC) case definitions for acute and chronic HCV infection
  • Discuss 2020 Centers for Disease Control (CDC) recommendations for HCV screening
  • List the 2020 US Preventive Services Task Force (USPSTF) screening recommendations for HCV infection
  • Summarize the rationale for universal HCV screening in the United States
  • Describe screening and supplemental tests used for diagnosing HCV infection
  • Summarize the recommended HCV testing sequence involving antibody and RNA testing
  • Discuss post-test counseling messages and linkage to care for persons with active HCV infection
  • Correctly interpret HCV testing results
  • Summarize common routes of HCV transmission
  • Discuss appropriate counseling to prevent transmission of HCV
  • Recognize the clinical features, if present, in persons with acute HCV infection
  • List appropriate tests to order for the laboratory diagnosis of acute HCV infection
  • Discuss the Centers for Disease Control and Prevention (CDC) case definition for acute HCV

Module 2. Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Module Core Competency
Provide Evidence-Based Evaluation, Staging, and Monitoring to Persons with Chronic Hepatitis C Infection
Lessons
Learning Objective Performance Indicators
  • Discuss key aspects of the medical history to obtain in a new evaluation of persons with HCV infection
  • Identify key abnormal physical examination findings that may be present in a person with HCV and cirrhosis
  • Summarize recommended laboratory studies to obtain for a person with HCV at the initial evaluation visit
  • List immunizations that should be administered to persons with chronic HCV infection
  • Summarize spontaneous viral clearance versus persistent infection following initial HCV acquisition
  • Describe the variable outcomes that can occur in persons with chronic HCV infection
  • List factors that influence the rate of progression of fibrosis in persons with chronic HCV infection
  • Discuss the impact of alcohol intake on fibrosis progression in persons with chronic HCV infection
  • Determine which common liver health counseling messages should be addressed in persons with chronic HCV infection
  • Explain recommendations for intake of acetaminophen and nonsteroidal antiinflammatory medications in persons with chronic HCV infection
  • Discuss key counseling messages related to coffee, diet, and complementary medications in persons with chronic HCV infection
  • Clarify guidance related to alcohol and marijuana use in persons with chronic HCV infection
  • Explain the indications, risks, and histologic assessment for liver biopsy in persons with chronic HCV infection
  • Discuss noninvasive Indirect and direct tests of liver fibrosis and examine the potential clinical utility of these tests
  • Summarize key radiologic methods that can estimate hepatic fibrosis
  • Differentiate compensated cirrhosis from decompensated cirrhosis
  • Explain the classification and prognostic systems for cirrhosis
  • Summarize important aspects of the medical history and physical examination in persons with cirrhosis
  • Describe key manifestations and complications associated with decompensated cirrhosis
  • Discuss the incidence of hepatocellular carcinoma in persons with chronic HCV
  • Describe the rationale for hepatocellular carcinoma surveillance in persons with chronic HCV infection
  • Compare different surveillance testing methods used for hepatocellular carcinoma surveillance
  • Summarize the American Association for the Study of Liver Diseases (AASLD) recommendations for surveillance for hepatocellular carcinoma
  • Identify the most common clinical syndromes associated with HCV-related cryoglobulinemia
  • Describe the renal extrahepatic manifestations associated with chronic HCV infection
  • Recognize the most common dermatologic extrahepatic manifestations associated with chronic HCV infection
  • Explain the relationship of chronic HCV infection and lymphomas

Module 3. Management of Cirrhosis-Related Complications

Module Core Competency
Apply Evidence-Based Recommendations to Management of Cirrhosis-Related Complications in Persons with HCV Infection
Lessons
Learning Objective Performance Indicators
  • Describe the appropriate technique for performing abdominal paracentesis
  • Summarize appropriate medical management and dietary recommendations for persons with ascites
  • Discuss ascites-associated complications and treatment
  • Differentiate spontaneous bacterial peritonitis from secondary bacterial peritonitis
  • Select and utilize appropriate antimicrobial therapy for persons with spontaneous bacterial peritonitis
  • Explain the importance of distinguishing secondary bacterial peritonitis from spontaneous bacterial peritonitis
  • Discuss the rationale for variceal screening in persons with cirrhosis
  • Identify individuals with cirrhosis who should receive primary prophylaxis against variceal bleeding
  • Use nonselective beta-blockers as prophylaxis against variceal bleeding when prophylaxis is indicated
  • List the clinical features of persons with hepatic encephalopathy
  • Summarize specific diagnostic tests used to diagnose hepatic encephalopathy
  • Use appropriate medical therapy for persons with hepatic encephalopathy
  • Summarize the indications and timing for cirrhosis-related liver transplantation evaluation and referral
  • Use and interpret the Model for End-Stage Liver Disease (MELD) prognostic scoring system
  • Discuss the absolute and relative contradictions for liver transplantation

Module 4. Evaluation and Preparation for Hepatitis C Treatment

Module Core Competency
Provide Evidence-Based Evaluation and Preparation for Treatment of Persons with Hepatitis C Infection
Lessons
Learning Objective Performance Indicators
  • Summarize the goals and rationale for HCV therapy in persons with chronic HCV
  • Discuss the long-term impact of HCV treatment in persons with chronic HCV
  • List several factors that potentially impact response to HCV treatment with direct-acting antiviral therapy
  • Summarize current recommendations for HCV treatment indications in persons with chronic HCV
  • Discuss relative and absolute contradictions for HCV treatment with direct-acting antiviral therapy
  • List specific monitoring studies when HCV treatment is deferred
  • Summarize the key steps in hepatitis C care continuum
  • List major barriers to hepatitis C testing
  • Describe approaches for improving linkage to hepatitis C care services 
  • Discuss strategies for expanding hepatitis C medical provider capacity

Module 5. Treatment of Chronic Hepatitis C Infection

Module Core Competency
Apply Evidence-Based Treatment of Chronic Hepatitis C Infection
Lessons
Learning Objective Performance Indicators
  • List key factors that influence the choice and duration of therapy for treating HCV genotype 1 infection
  • Describe the circumstances for NS5A genotypic drug resistance testing
  • Discuss preferred therapies for initial treatment of treatment-naïve adults with HCV genotype 1 infection
  • List the preferred therapies for retreatment of adults with chronic HCV genotype 1 infection who have previously failed therapy
  • List preferred therapies for initial treatment of adults with HCV genotype 2 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 2 chronic infection who have failed prior therapy
  • List preferred therapies for initial treatment of adults with HCV genotype 3 chronic infection
  • Describe the preferred therapy for retreatment of adults with HCV genotype 3 chronic infection who have failed prior therapy
  • Understand the preferred therapies for the initial treatment of adults with HCV genotype 4 chronic infection
  • State the preferred therapy for retreatment of adults with HCV genotype 4 chronic infection in whom prior therapy has failed
  • List the preferred therapies for the initial treatment of adults with HCV genotype 5 or 6 chronic infection
  • Discuss the preferred approach to retreatment of adults with HCV genotype 5 or 6 chronic infection who have failed prior therapy
  • List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
  • Discuss monitoring for hepatitis B virus reactivation during HCV therapy
  • Summarize appropriate monitoring for patients after HCV treatment

Module 6. Treatment of Key Populations and Unique Situations

Module Core Competency
Apply Evidence-Based HCV Treatment to Key Populations and in Unique Situations
Lessons
Learning Objective Performance Indicators
  • Explain the concept of spontaneous HCV clearance after acute infection and how this impacts treatment strategies
  • Formulate an approach to evaluation and treatment of persons with acute HCV infection
  • Summarize treatment recommendations for persons diagnosed with acute HCV infection
  • Explain the impact of HIV on coinfection with HCV
  • Discuss sustained virologic response (SVR) outcomes demonstrated in key studies using direct-acting antiviral agents to treat HCV in persons with HIV coinfection
  • Differentiate HCV treatment duration for HCV monoinfection versus HCV-HIV coinfection
  • Summarize recommendations for monitoring persons with HCV-HIV coinfection after initiating antiretroviral therapy
  • Highlight drug interactions from the perspective of direct-acting antivirals and antiretroviral medication classes
  • Explain the interaction of HCV and renal disease
  • Discuss HCV treatment approaches in persons with chronic renal insufficiency
  • Summarize HCV treatment recommendations in persons following renal transplantation
  • Distinguish persons with compensated cirrhosis from those with decompensated cirrhosis
  • Summarize the impact of treating HCV in persons with cirrhosis
  • Provide appropriate HCV treatment options for persons with compensated cirrhosis
  • Discuss approaches to treatment of HCV in persons with decompensated cirrhosis
  • Summarize the impact of substance use on HCV treatment decisions 
  • Describe HCV treatment responses in persons with substance use disorders compared with those who do not have substance use disorders
  • Integrate support services and management strategies into programs for persons with substance use disorders who have chronic HCV infection
  • Describe HCV prevalence in the correctional setting
  • Summarize HCV screening in correctional setting
  • Discuss challenges of treating HCV in corrections
  • List the definition for health care personnel
  • Estimate the risk of HCV seroconversion after an occupational exposure to HCV
  • Describe management of health care personnel exposed to HCV, based on type and nature of exposure
  • Discuss monitoring and follow-up testing of health care personnel after an occupational exposure to HCV
  • Describe the current guidelines for HCV screening in pregnant women
  • Identify the risk of mother-to-child transmission of HCV and factors associated with increased risk of transmission
  • Summarize the impact of HCV on pregnancy outcomes
  • Describe interventions or prophylactic measures to reduce the risk of mother-to-child transmission of HCV

Curriculum Progress Tracker - 3rd Edition

Curated Curriculum 1Self-Study Module 1
For any clinician who may encounter persons with hepatitis C virus infection and would like to establish core competence in testing for hepatitis C, counseling patients on preventing hepatitis C transmission, and diagnosing acute hepatitis C infection.
Curated Curriculum 2Self-Study Module 2
Intended for clinicians involved in long-term management of persons with chronic hepatitis C infection. Content includes initial evaluation, natural history, preventing liver damage, staging of liver fibrosis, evaluation of cirrhosis, surveillance for hepatocellular carcinoma, and recognition of extrahepatic manifestations.
Curated Curriculum 3Self-Study Module 3
Addresses the diagnosis and management of complications that may arise in person with chronic HCV infection and cirrhosis, including ascites, spontaneous bacterial peritonitis, varicies, hepatic encephalopathy, and referral for liver transplantation.
Curated Curriculum 4Self-Study Module 4
For clinicians evaluating persons with chronic HCV infection for hepatitis C treatment, including clinicians who will independently assess treatment candidacy and clinicians who will provide treatment candidacy with assistance from a hepatitis C expert.
Curated Curriculum 5Self-Study Module 5
For clinicians treating chronic hepatitis C infection. Material covered includes recommendations for treatment-naïve and treatment-experienced persons with chronic HCV infection genotypes 1-6, based on the Association for the Study of Liver Diseases and Infectious Diseases Society of America (AASLD-IDSA) HCV Guidance.
Curated Curriculum 6Self-Study Module 6
Designed for clinicians who manage key populations of persons living with HCV and/or complex HCV-related unique treatment issues. Material covered is at an advanced level.
Lesson 1 
 
 
 
 
 
Lesson 2 
 
 
 
 
 
Lesson 3 
 
 
 
 
 
Lesson 4 
 
 
 
 
Lesson 5 
 
 
 
 
Lesson 6 
 
 
Lesson 7 
 
Lesson 8 
Self-Assessment

Curriculum Progress Tracker - 2nd Edition

2nd Edition. There is a newer edition of this curriculum.
Curated Curriculum 1Self-Study Module 1
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
For any clinician who may encounter persons with hepatitis C virus infection and would like to establish core competence in testing for hepatitis C, counseling patients on preventing hepatitis C transmission, and diagnosing acute hepatitis C infection.
Curated Curriculum 2Self-Study Module 2
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
Intended for clinicians involved in long-term management of persons with chronic hepatitis C infection. Content includes initial evaluation, natural history, preventing liver damage, staging of liver fibrosis, evaluation of cirrhosis, surveillance for hepatocellular carcinoma, and recognition of extrahepatic manifestations.
Curated Curriculum 3Self-Study Module 3
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
Addresses the diagnosis and management of complications that may arise in person with chronic HCV infection and cirrhosis, including ascites, spontaneous bacterial peritonitis, varicies, hepatic encephalopathy, and referral for liver transplantation.
Curated Curriculum 4Self-Study Module 4
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
For clinicians evaluating persons with chronic HCV infection for hepatitis C treatment, including clinicians who will independently assess treatment candidacy and clinicians who will provide treatment candidacy with assistance from a hepatitis C expert.
Curated Curriculum 5Self-Study Module 5
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
For clinicians treating chronic hepatitis C infection. Material covered includes recommendations for treatment-naïve and treatment-experienced persons with chronic HCV infection genotypes 1-6, based on the Association for the Study of Liver Diseases and Infectious Diseases Society of America (AASLD-IDSA) HCV Guidance.
Curated Curriculum 6Self-Study Module 6
2nd Edition. There is a newer edition of this Curated Curriculum. This is your progress from the previous edition (2nd).
Designed for clinicians who manage key populations of persons living with HCV and/or complex HCV-related unique treatment issues. Material covered is at an advanced level.
Lesson 1 
 
 
 
 
 
Lesson 2 
 
 
 
 
 
Lesson 3 
 
 
 
 
 
Lesson 4 
 
 
 
 
 
Lesson 5 
 
 
 
 
Lesson 6 
 
 
Lesson 7 
Self-Assessment

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