Model for End-Stage Liver Disease (MELD) 3.0 for ages 12 and older
The Model for Liver Disease (MELD) predicts survival for persons with advanced liver disease.
MELD 3.0
Gender
Interpretation:
3-Month Mortality Based on MELD 3.0 Score
The estimated 3-month mortality is based on the MELD score highlighted in yellow above. It is calculated using the following formula:
Estimated 90-day survival = 0.946 ^ exp(0.17698*MELD 3.0 – 3.56) * 100
Formula and Notes
MELD 3.0 = round(1.33*(Female) + 4.56*ln(Serum bilirubin) + 0.82*(137 - Sodium) - 0.24*(137 - Sodium)*ln(Serum bilirubin) + 9.09*ln(INR) + 11.14*ln(Serum creatinine) + 1.85*(3.5 - Serum albumin) - 1.83*(3.5 - Serum albumin)*ln(Serum creatinine) + 6)
Notes
- The MELD utilizes natural log transformation such that any value less than 1 is automatically given a lower limit value of 1 to prevent generating a negative score.
- The lower limit of serum sodium (Na) is capped at 125, and the upper limit is capped at 137.
- The lower limit of serum albumin is capped at 1.5, and the upper limit is capped at 3.5.
- The upper limit of serum creatinine is capped at 3.
Sources
- Kamath PS, Kim WR; Advanced Liver Disease Study Group. The model for end-stage liver disease (MELD). Hepatology. 2007;45:797-805.[PubMed Abstract] -
- Kim WR, Mannalithara A, Heimbach JK, et al. MELD 3.0: The Model for End-Stage Liver Disease Updated for the Modern Era. Gastroenterology. 2021;161:1887-95.[PubMed Abstract] -
- Wiesner R, Edwards E, Freeman R, et al. Model for end-stage liver disease (MELD) and allocation of donor livers. Gastroenterology. 2003;124:91-6.[PubMed Abstract] -
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