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Treatment of Key Populations and Unique Situations Overview4th Edition

Module Core Competency

Apply Evidence-Based HCV Treatment to Key Populations and in Unique Situations

Target Audience

Examine how to treat HCV in persons with HIV coinfection, renal impairment, and substance use. Develop an understanding of how to manage exposure to HCV in the workplace and learn about perinatal HCV transmission.

Editors

H. Nina Kim, MD, MSc

H. Nina Kim, MD, MSc
Associate Editor
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

Maria A. Corcorran, MD, MPH

Maria A. Corcorran, MD, MPH
Associate Editor
Assistant Professor
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

1Lesson 1 Treatment of HCV in Persons with HIV Coinfection

Learning Objectives
- Explain the impact of HIV on the progression of liver fibrosis in persons with untreated chronic HCV
- Describe current HCV treatment approaches in persons with HIV coinfection
- Discuss HCV treatment responses in persons with HIV and HCV coinfection compared with responses in persons with HCV monoinfection
- Summarize recommendations for treating HIV in persons with HCV and HIV coinfection
- List key drug interactions between HCV direct-acting antivirals and HIV antiretroviral medications
Quick ReferenceTreatment of HCV in Persons with HIV Coinfection Core Concepts
Activity 1B.DHHS Guidelines for HCV-HIV Coinfection

2Lesson 2 Treatment of HCV in Persons with Renal Impairment

Learning Objectives
- Explain the impact of HCV on renal disease
- Summarize the main findings from HCV treatment studies in people with renal disease
- Discuss dosing of direct-acting antiviral medications in persons with chronic renal disease
- Describe appropriate HCV treatment in persons prior to renal transplantaton
- Summarize HCV treatment recommendations in persons following renal transplantation
Quick ReferenceTreatment of HCV in Persons with Renal Impairment Core Concepts
Activity 2B.GFR Calculator

3Lesson 3 Treatment of HCV in Persons with Substance Use

Learning Objectives
- Discuss the prevalence of substance use among persons in the United States
- Describe HCV treatment responses in persons with substance use disorders compared with those who do not have substance use disorders
- Summarize HCV treatment eligibility in persons who have a past or current substance use disorder
- List support services and management strategies for persons with substance use disorders who have chronic HCV infection
- Explain the concept of HCV reinfection in persons who inject drugs
Quick ReferenceTreatment of HCV in Persons with Substance Use Core Concepts

4Lesson 4 Treatment of HCV in a Correctional Setting

Learning Objectives
- Describe HCV prevalence in the correctional setting
- Explain the difference between jails and prisons
- Summarize HCV screening recommendations in correctional settings
- State recommendations for HCV treatment eligibility in prisons
- Discuss HCV treatment approach in prisons
Quick ReferenceTreatment of HCV in a Correctional Setting Core Concepts

5Lesson 5 Management of Health Care Personnel Exposed to HCV

Learning Objectives
- List the definition of health care personnel
- Estimate the risk of HCV seroconversion after an occupational exposure to HCV that involves a needlestick injury
- Describe management of health care personnel exposed to HCV, based on type and nature of exposure
- Summarize monitoring and follow-up testing of health care personnel after occupational exposure to HCV
- Discuss the treatment approach for health care personnel who acquire HCV from an occupational exposure
Quick ReferenceManagement of Health Care Personnel Exposed to HCV Core Concepts

6Lesson 6 Perinatal HCV Transmission

Learning Objectives
- Describe the current guidelines for HCV screening in pregnant women
- Identify the risk of mother-to-child transmission of HCV and factors associated with increased risk of transmission
- Summarize the impact of HCV on pregnancy outcomes
- Describe interventions and/or prophylactic measures to reduce the risk of mother-to-child transmission of HCV
- List recommendations for HCV testing and management in infants born to mothers with HCV.
Quick ReferencePerinatal HCV Transmission Core Concepts

The Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.

HCV Test and Cure

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Management of Cirrhosis-Related Complications

Evaluation and Preparation for Hepatitis C Treatment

Treatment of Hepatitis C Infection