Quick Reference

HCV Test and Cure Overview4th Edition

Target Audience

In this hepatitis C fundamentals 5-hour, highly interactive module, health care providers will develop core proficiency in screening and diagnosing hepatitis C, providing simplified treatment of hepatitis C with direct acting antivirals (DAAs), and assessing for cure. Learners who complete all five lessons in this module may take an optional 20-question knowledge assessment test and earn an HCV Test and Cure Training Certificate.

1Lesson 1 Epidemiology and Natural History

Learning Objectives
- Increase treatment rates in the United States for adults with hepatitis C virus (HCV) infection
- Describe key epidemiologic features of HCV infection in the United States
- Utilize knowledge about HCV acquisition to prevent new HCV infections
- Recognize the progression of liver disease in untreated HCV infection
- Adopt the simplified HCV treatment approach to expand treatment of HCV by primary care clinicians
Quick ReferenceEpidemiology and Natural History Core Concepts
Activity 1B.Welcome Video

2Lesson 2 Screening, Diagnosis, and Prevention

Learning Objectives
- Perform universal HCV screening in persons in the United States
- Recognize HCV acquisition factors to inform periodic, repeat HCV testing
- Effectively implement HCV testing sequence recommendations from the Centers for Disease Control and Prevention
- Correctly interpret HCV antibody and HCV RNA test results to determine HCV status
- Counsel persons with HCV on how to prevent HCV transmission
Quick ReferenceScreening, Diagnosis, and Prevention Core Concepts
Activity 2B.Interpretation of HCV Diagnostic Laboratory Test Results
Activity 2C.Strategies for Implementing Hepatitis C Virus Point-of-Care Testing

3Lesson 3 Pretreatment Evaluation and Fibrosis Staging

Learning Objectives
- Initiate a comprehensive clinical and laboratory evaluation prior to treating a person for HCV infection
- Obtain the recommended core set of laboratory tests indicated for persons prior to starting HCV treatment
- Differentiate laboratory testing recommendations in persons with HCV based on cirrhosis status
- Correctly interpret test results for noninvasive assessment tools used to stage liver fibrosis
- Recognize the conditions that would lead to a presumptive diagnosis of decompensated cirrhosis
Quick ReferencePretreatment Evaluation and Fibrosis Staging Core Concepts
Activity 3B.FibroScan: A Clinician's Guide
Activity 3C.Calculating FIB-4 Score
Activity 3D.Calculating a CTP Score

4Lesson 4 HCV Simplified Treatment

Learning Objectives
- Provide a rationale for treating all people with HCV except persons with less than a 12-month life expectancy
- Adhere to inclusion and exclusion criteria for who is eligible to receive simplified HCV treatment
- Choose an appropriate recommended regimen for simplified HCV treatment
- Conduct laboratory monitoring for persons receiving simplified HCV treatment, including assessment for sustained virologic response
- Manage incomplete treatment adherence based on time into treatment and number of days of missed doses
Quick ReferenceHCV Simplified Treatment Core Concepts
Activity 4B.HCV Point of Care Testing and the Test and Treat Approach
Activity 4C.Simplified Treatment Criteria
Activity 4D.Recommended Regimens for Simplified Treatment Approach
Activity 4E.Follow up After the HCV Test and Treat Approach
Activity 4F.Initiation of HCV Treatment in Person with Alcohol Use Disorder
Activity 4G.Glecaprevir-Pibrentasvir Treatment with Compensated Cirrhosis
Activity 4H.Sofosbuvir-Velapatasvir Treatment with Compensated Cirrhosis
Activity 4I.Drug Interactions with Glecaprevir-Pibrentasvir
Activity 4J.Drug Interactions with Sofosbuvir-Velpatasvir
Activity 4K.Management of Treatment Interruption with less than 7 Missed Days
Activity 4L.Management of Treatment Interruption After Missing 8-20 Days

5Lesson 5 Follow-Up and Promoting Liver Health

Learning Objectives
- Perform follow-up monitoring of persons after treatment for chronic HCV
- Obtain an HCV RNA assay as appropriate to screen for HCV reinfection after a person clears HCV
- Administer priority immunizations for people with chronic HCV
- Engage a person with chronic or cleared HCV in a discussion about measures that promote liver health
- Institute routine screening for hepatocellular carcinoma and varices for persons with cirrhosis
Quick ReferenceFollow-Up and Promoting Liver Health Core Concepts
Activity 5B.Determing AUDIT-C Score
Activity 5C.NIH Liver Tox

The Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.

HCV Test and Cure

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Evaluation and Preparation for Hepatitis C Treatment

Treatment of Hepatitis C Infection

Treatment of Key Populations and Unique Situations

HCV Test and Cure

HCV Test and Cure Training Certificate

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Evaluation and Preparation for Hepatitis C Treatment

Treatment of Hepatitis C Infection

Treatment of Key Populations and Unique Situations

Elbasvir-Grazoprevir

Glecaprevir-Pibrentasvir

Ledipasvir-Sofosbuvir

Ribavirin

Sofosbuvir

Sofosbuvir-Velpatasvir

Sofosbuvir-Velpatasvir-Voxilaprevir

HCV Test and Cure Overview4th Edition

Target Audience

1Lesson 1 Epidemiology and Natural History

2Lesson 2 Screening, Diagnosis, and Prevention

3Lesson 3 Pretreatment Evaluation and Fibrosis Staging

4Lesson 4 HCV Simplified Treatment

5Lesson 5 Follow-Up and Promoting Liver Health

You must be signed in to customize your interaction with these questions.

HCV Test and Cure

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Management of Cirrhosis-Related Complications

Evaluation and Preparation for Hepatitis C Treatment

Treatment of Hepatitis C Infection

Treatment of Key Populations and Unique Situations

HCV Test and Cure

HCV Test and Cure Training Certificate

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Management of Cirrhosis-Related Complications

Evaluation and Preparation for Hepatitis C Treatment

Treatment of Hepatitis C Infection

Treatment of Key Populations and Unique Situations

Elbasvir-Grazoprevir

Glecaprevir-Pibrentasvir

Ledipasvir-Sofosbuvir

Ribavirin

Sofosbuvir

Sofosbuvir-Velpatasvir

Sofosbuvir-Velpatasvir-Voxilaprevir

HCV Test and Cure Overview4th Edition

Target Audience

1Lesson 1 Epidemiology and Natural History

2Lesson 2 Screening, Diagnosis, and Prevention

3Lesson 3 Pretreatment Evaluation and Fibrosis Staging

4Lesson 4 HCV Simplified Treatment

5Lesson 5 Follow-Up and Promoting Liver Health

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