Treatment of Chronic Hepatitis C Infection Overview

• Learning Objectives
  1. Discuss preferred therapies for initial treatment of adults with HCV genotype 1a or 1b chronic infection.
  2. List the preferred therapy for retreatment of adults with HCV genotype 1a or 1b chronic infection who have previously failed therapy.
• Quick ReferenceTreatment of HCV Genotype 1 Core Concepts
  • Introduction
  • HCV Genotype 1: Initial Treatment
  • Studies of Initial Treatment of Adults with HCV Genotype 1
  • HCV Genotype 1: Retreatment of Persons who Failed Prior Therapy
  • Studies of Retreatment of Adults with HCV Genotype 1
  • Summary Points
• Self-Study CNE/CMETreatment of HCV Genotype 1 Lesson

Hands-On Activities

• Activity 1B.AASLD-IDSA Hepatitis C Guidance
• Activity 1C.Choices for Initial Treatment of Patients with Genotype 1a Chronic HCV

• Learning Objectives
  1. List preferred therapies for initial treatment of adults with HCV genotype 2 chronic infection.
  2. Describe the preferred therapy for retreatment of adults with HCV genotype 2 chronic infection who have failed prior therapy.
• Quick ReferenceTreatment of HCV Genotype 2 Core Concepts
  • Introduction
  • HCV Genotype 2: Initial Treatment
  • Studies of Initial Treatment of Adults with HCV Genotype 2
  • HCV Genotype 2: Retreating Persons who Failed Prior Therapy
  • Studies of Retreatment of Adults with HCV Genotype 2
  • Summary Points
• Self-Study CNE/CMETreatment of HCV Genotype 2 Lesson

Hands-On Activities

• Activity 2B.EASL Recommendations on Treatment of Hepatitis C 2016

• Learning Objectives
  1. List preferred therapies for initial treatment of adults with HCV genotype 3 chronic infection.
  2. Describe the preferred therapy for retreatment of adults with HCV genotype 3 chronic infection who have failed prior therapy.
• Quick ReferenceTreatment of HCV Genotype 3 Core Concepts
  • Introduction
  • HCV Genotype 3: Initial Treatment
  • Studies of Initial Treatment of Adults with HCV Genotype 3
  • HCV Genotype 3: Retreating Persons who Failed Prior Therapy
  • Studies of Retreatment of Adults with HCV Genotype 3
  • Summary Points
• Self-Study CNE/CMETreatment of HCV Genotype 3 Lesson

Hands-On Activities

• Activity 3B.VA Treatment Considerations
• Activity 3C.Choices for Initial Treatment of Patients with HCV Genotype 3

• Learning Objectives
  1. Understand the preferred therapies for the initial treatment of adults with HCV genotype 4 chronic infection.
  2. State the preferred therapy for retreatment of adults with HCV genotype 4 chronic infection in whom prior therapy has failed.
• Quick ReferenceTreatment of HCV Genotype 4 Core Concepts
  • Introduction
  • HCV Genotype 4: Initial Treatment
  • Studies of Initial Treatment of Adults with HCV Genotype 4
  • HCV Genotype 4: Retreating Persons who Failed Prior Therapy
  • Studies of Retreatment of Adults with HCV Genotype 4
  • Summary Points
• Self-Study CNE/CMETreatment of HCV Genotype 4 Lesson

Hands-On Activities

• Activity 4B.Hepatitis C Clinical Trials

• Learning Objectives
  1. List the preferred therapies for the initial treatment of adults with HCV genotype 5 or 6 chronic infection.
  2. Discuss the preferred approach to retreatment of adults with HCV genotype 5 or 6 chronic infection who have failed prior therapy.
• Quick ReferenceTreatment of HCV Genotype 5 or 6 Core Concepts
  • Introduction
  • HCV Genotype 5 or 6: Initial Treatment
  • Studies of Initial Treatment of Adults with HCV Genotype 5 or 6
  • HCV Genotype 5 or 6: Retreating Persons who Failed Prior Therapy
  • Studies of Retreatment of Adults with HCV Genotype 5 or 6
  • Summary Points
• Self-Study CNE/CMETreatment of HCV Genotype 5 or 6 Lesson

Hands-On Activities

• Activity 5B.NATAP Web Site

• Learning Objectives
  1. List the recommended monitoring for treatment efficacy and safety in patients receiving HCV therapy.
  2. Summarize appropriate monitoring for patients after HCV treatment.
• Quick ReferenceMonitoring During and After HCV Treatment Core Concepts
  • Background
  • Monitoring for Treatment Efficacy
  • Monitoring for Safety During Treatment
  • Hepatitis B Reactivation Associated with HCV DAA Therapy
  • Monitoring After Receiving HCV Therapy
  • Summary Points
• Self-Study CNE/CMEMonitoring During and After HCV Treatment Lesson