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Treatment of Hepatitis C Infection Overview4th Edition

Module Core Competency

Apply Evidence-Based Treatment for Hepatitis C Infection

Target Audience

Learn about simplified HCV treatment for all HCV genotypes and how to treat persons with prior HCV treatment experience, cirrhosis, or acute HCV infection.

Editors

H. Nina Kim, MD, MSc

H. Nina Kim, MD, MSc
Associate Editor
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

Maria A. Corcorran, MD, MPH

Maria A. Corcorran, MD, MPH
Associate Editor
Assistant Professor
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

1Lesson 1 Simplified HCV Treatment for All HCV Genotypes

Learning Objectives
- Summarize the eligibility criteria for the American Association for the Study of Liver Disease/Infectious Diseases Society of America (AASLD/IDSA) simplified HCV treatment algorithm
- Discuss how to assess liver fibrosis, including identifying decompensated cirrhosis
- List the direct-acting antiviral (DAA) treatment regimens recommended as part of the AASLD/IDSA simplified guidance
- Describe on-treatment monitoring for adults during HCV treatment using the simplified AASLD/IDSA guidance
- Describe appropriate post-treatment monitoring for adults after completing HCV treatment
Quick ReferenceSimplified HCV Treatment for All HCV Genotypes Core Concepts

2Lesson 2 Retreatment of Patients with Prior HCV Treatment Experience

Learning Objectives
- Discuss the approach to retreatment of patients with chronic hepatitis C in the direct-acting antiviral (DAA) era
- List the preferred therapeutic combinations for retreatment in persons with prior sofosbuvir-containing regimens
- Describe recommended options for retreatment in persons with prior treatment with elbasvir-grazoprevir
- Review preferred retreatment options for persons with prior treatment with glecaprevir-pibrentasvir
- Summarize options for persons with multiple prior DAA treatment failures
Quick ReferenceRetreatment of Patients with Prior HCV Treatment Experience Core Concepts

3Lesson 3 Monitoring During and After HCV Treatment

Learning Objectives
- List the recommended monitoring for treatment efficacy and safety in adults receiving HCV therapy
- Discuss monitoring for hepatitis B virus reactivation during HCV therapy
- Summarize the approach to persons with elevated alanine aminotransferase levels (ALT) during therapy
- Define sustained virologic response
- Describe appropriate monitoring for patients after HCV treatment
Quick ReferenceMonitoring During and After HCV Treatment Core Concepts

4Lesson 4 Treatment of HCV in Persons with Cirrhosis

Learning Objectives
- Distinguish persons with compensated cirrhosis from those with decompensated cirrhosis
- Summarize the impact of treating HCV in persons with cirrhosis
- Discuss major studies involving regimens with pangenotypic activity used to treat HCV in persons with compensated cirrhosis
- Provide appropriate HCV treatment options for persons with compensated cirrhosis
- List approaches to treatment of HCV in persons with decompensated cirrhosis
Quick ReferenceTreatment of HCV in Persons with Cirrhosis Core Concepts
Activity 4B.Understanding Liver Biopsy Results

5Lesson 5 Treatment of Acute HCV Infection

Learning Objectives
- Discuss HCV epidemiologic features of acute hepatitis C virus (HCV) infection in the United States
- Explain spontaneous HCV clearance after acute infection and its impact on treatment strategies
- Formulate an approach to evaluate and treat persons with acute HCV infection
- Describe timing for initiating treatment of persons with acute HCV infection
- Summarize recommendations for treatment regimens for persons with acute HCV infection
Quick ReferenceTreatment of Acute HCV Infection Core Concepts

The Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.

HCV Test and Cure

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C

Evaluation and Preparation for Hepatitis C Treatment