Quick Reference

Treatment of Hepatitis C Infection Overview4th Edition

Module Core Competency

Apply Evidence-Based Treatment for Hepatitis C Infection

Target Audience

Learn about the goals and benefits of HCV treatment and how to provide simplified HCV treatment for all HCV genotypes, treat persons with prior HCV treatment experience, and address structural barriers to expand treatment access.

Editors

H. Nina Kim, MD, MSc

H. Nina Kim, MD, MSc
Editor
Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

Maria A. Corcorran, MD, MPH

Maria A. Corcorran, MD, MPH
Editor
Associate Professor of Medicine
Division of Allergy & Infectious Diseases
University of Washington

Disclosures: None

1Lesson 1 Goals and Benefits of HCV Treatment

Learning Objectives
- Identify four goals of hepatitis C virus (HCV) therapy in persons with chronic HCV
- Recognize the indicators for determining sustained virologic response (SVR)
- Describe the impact on survival and quality of life if SVR is achieved after HCV treatment
- Identify the impact of HCV treatment on hepatic fibrosis, hepatocellular carcinoma, and extrahepatic manifestations
- Describe the population-level health and economic benefits of HCV elimination
Quick ReferenceGoals and Benefits of HCV Treatment Core Concepts

2Lesson 2 Simplified HCV Treatment for All Genotypes

Learning Objectives
- Identify persons with chronic hepatitis C virus (HCV) infection who meet AALSD/IDSA eligibility criteria for simplified HCV treatment
- Conduct an appropriate pre-treatment assessment of adults without cirrhosis or with compensated cirrhosis
- Initiate direct-acting antiviral (DAA) treatment as recommended in the AASLD/IDSA simplified guidance
- Collaboratively provide on-treatment monitoring for adults during HCV treatment using the AASLD/IDSA guidance
- Evaluate for post-treatment virologic cure and required follow-up based on achievement of virologic cure
Quick ReferenceSimplified HCV Treatment for All Genotypes Core Concepts

3Lesson 3 Retreatment of Persons with Prior HCV Treatment Experience

Learning Objectives
- Recognize when retreatment of patients with chronic hepatitis C is warranted in the direct-acting antiviral (DAA) era
- Initiate HCV retreatment with a recommended regimen in persons who experienced treatment failure with sofosbuvir-containing regimens
- Initiate HCV retreatment with a recommended regimen in persons who experienced treatment failure with elbasvir-grazoprevir
- Initiate retreatment with a recommended regimen in persons who experienced treatment failure with glecaprevir-pibrentasvir
- Collaborate with an HCV or liver specialist to determine retreatment options for persons with multiple prior DAA treatment failures
Quick ReferenceRetreatment of Persons with Prior HCV Treatment Experience Core Concepts

4Lesson 4 Addressing Structural Barriers to HCV Treatment

Learning Objectives
- Summarize the major HCV care continuum benchmarks
- Initiate HCV screening based on the Centers for Disease Control and Infection (CDC) recommendations
- Collaborate with community-based organizations to improve access to HCV testing, including point-of-care testing
- Facilitate strategies to improve linkage to care for persons who test positive for HCV infection
- Identify opportunities to integrate HCV care into other routine care services provided in non-traditional care settings
Quick ReferenceAddressing Structural Barriers to HCV Treatment Core Concepts

The Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.

HCV Test and Cure

Screening and Diagnosis of Hepatitis C Infection

Evaluation, Staging, and Monitoring of Chronic Hepatitis C