Purpose / DescriptionIn an observational cohort study conducted in the Veterans Administration system, investigators used the Electronically Retrieved Cohort of HCV-Infected Persons (ERCHIVES) to analyze HCV treatment responses for 13,663 persons who received ledipasvir-sofosbuvir, with or without ribavirin. This cohort included a total of 1,607 with CKD stage 3, 4, or 5 who completed HCV treatment.[25] The SVR12 rates for individuals with stage 3 CDK who completed treatment was 97.0% (1080 of 1113) in those who received ledipasvir-sofosbuvir and 97.1% (375 of 386) with ledipasvir-sofosbuvir plus ribavirin. For those with stage 4 or 5 CKD, the SVR12 rates were 94.0% (78 of 83) with ledipasvir-sofosbuvir and 100% (25 of 25) with ledipasvir-sofosbuvir plus ribavirin. The ERCHIVES-Renal also included analysis of persons with CKD and HCV treatment responses to ombitasvir-paritaprevir-ribavirin and dasabuvir, with or without ribavirin.