Activity 4B. Understanding Liver Biopsy Results PDF Share Learning Objective Performance Indicators Distinguish persons with compensated cirrhosis from those with decompensated cirrhosis Summarize the impact of treating HCV in persons with cirrhosis Discuss major studies involving regimens with pangenotypic activity used to treat HCV in persons with compensated cirrhosis Provide appropriate HCV treatment options for persons with compensated cirrhosis List approaches to treatment of HCV in persons with decompensated cirrhosis InstructionsGiven the extremely high cost of new direct-acting antiviral agents for the treatment of hepatitis C, many insurance companies and large health care organizations have prioritized treatment of hepatitis C for those individuals with advanced fibrosis or cirrhosis. Further, documentation of advanced fibrosis or cirrhosis is now often required prior to treatment. For clinicians who lack experience and expertise in understanding liver biopsy results, see the link to the excellent review—Liver biopsy assessment in chronic viral hepatitis—by Dr. Neil Theise, a pathologist at the Beth Israel Medical Center. In particular, review the brief section Caveats Regarding Specimen Adequacy (near the end of the section, "So What do I do"?) and also note the diagrams (Figures 3 and 5) that conceptually help to explain the difference in liver biopsy necroinflammatory activity and scarring (fibrosis).Open Understanding Liver Biopsy Results Activity QuestionYou should answer this question after completing the activity. You must answer all of the questions before checking your work. This activity has a Check on Learning question. - Show Question When a patient with chronic hepatitis C infection undergoes liver biopsy to evaluate the stage of their liver disease, it is critical that adequate samples are obtained for reliable accuracy of the histologic assessment. Which one of the following best describes a generally accepted standard for ensuring the adequacy of the liver biopsy specimen? Tissue samples from 4 distinct lobes of the liver Tissue samples that contain 3 distinct sinusoidal regions Tissue samples that are at least 1 cm in length and represent 3 or more regions of the liver Tissue samples that are at least 2 cm in length and contains 11 to 15 portal tracts Share by e-mail From:Enter your e-mail address To: Enter the e-mail address of the recipient Your Message: Check-On-LearningQuestionsThe Check-on-Learning Questions are short and topic related. They are meant to help you stay on track throughout each lesson and check your understanding of key concepts.You must be signed in to customize your interaction with these questions.
