Activity 4L. Management of Treatment Interruption After Missing 8-20 Days

Learning Objective Performance Indicators

  • Provide a rationale for treating all people with HCV except persons with less than a 12-month life expectancy
  • Adhere to inclusion and exclusion criteria for who is eligible to receive simplified HCV treatment
  • Choose an appropriate recommended regimen for simplified HCV treatment
  • Conduct laboratory monitoring for persons receiving simplified HCV treatment, including assessment for sustained virologic response
  • Manage incomplete treatment adherence based on time into treatment and number of days of missed doses

Activity Question

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A 47-year-old man with chronic HCV genotype 1 and compensated cirrhosis is taking a scheduled 12-week HCV treatment course of sofosbuvir-velpatasvir. At week 7 of the treatment she has a febrile diarrheal illness and he stops taking sofosbuvir-valpatasvir for 9 days. He is seen in clinic and diagnosed with shigella on the same day as the clinic visit based on a multiplex enteric stool PCR test. Treatment for shigella is started and he is told to restart sofosbuvir-velpatasvir. An HCV RNA level is drawn and the result returns 2 days later as undetectable.

What should be recommended regarding the sofosbuvir-velpatasvir treatment?

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